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ML 348
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML 348图片
CAS NO:899713-86-1
规格:98%
分子量:415.79
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
lysophospholipase 1 (LYPLA1) inhibitor
CAS:899713-86-1
分子式:C18H17ClF3N3O3
分子量:415.79
纯度:98%
存储:Store at -20°C

Background:

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].


ML348 (5 μM; 3 hours ) selectively inhibits LYPLA1 in cultured cells[1].


ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice[1].


参考文献:
[1]. Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). National Center for Biotechnology Information (US); 2010- 2013 Apr 08.