Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively).
CAS：862073-79-8
分子式：C22H28O9S
分子量：468.5
纯度：98%
存储：Store at -20°C

Background:

Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively). It is a mesylated version of salvinorin B and is highly selective for κ-opioid receptors over µ- and δ-opioid receptors. In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane. In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.