Silvestrol aglycone 是 Silvestrol 的类似物，能够抑制癌细胞蛋白翻译起始，对蛋白翻译荧光素酶报告基因 yc-LUC 和 tub-LUC 的 EC50 值分别为 10 和 200 nM。具有抗癌作用。
CAS：960365-65-5
分子式：C27H26O8
分子量：478.49
纯度：98%
存储：Store at -20°C

Background:

Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity[1].

Silvestrol aglycone (Compound 4) inhibits the proliferation of MDA-MB-231 cells with an E50 of 20 ± 10 nM after 72 h[1].

[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.