MBM-17 (compound 42c) 是有效的 NIMA-related kinase 2 (Nek2) 抑制剂，IC50 值为 3 nM，通过诱导细胞周期停滞和凋亡，抑制癌细胞的增殖，具有抗肿瘤活性，且对小鼠没有明显的毒性。
CAS：2083621-90-1
分子式：C28H28N6O2
分子量：480.56
纯度：98%
存储：Store at -20°C

Background:

MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]

MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].

[1]. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.