Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS.
CAS：87377-08-0
分子式：C19H12ClD4NO4
分子量：361.8
纯度：98%
存储：Store at -20°C

Background:

Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS. Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively). It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes. Indomethacin reduces ocular inflammation induced by bovine serum in rabbits. It also reduces paw edema in a rat model of carrageenan-induced inflammation.