Sacubitril sodium

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Sacubitril sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	149690-05-1
规格:	≥98%

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1g	电议
2g	电议

产品介绍

Sacubitril sodium (also known as AHU-377), the sodium salt of Sacubitril, is an NEP (neutral endopeptidase 24.11) inhibitor (IC50 = 5 nM) used as a component of the heart failure medicine LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan). As a prodrug, Sacubitril has to be activated to LBQ-657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.

理化性质和储存条件

	ame: Sacubitril sodium CAS#: 149690-05-1 (sodium) Chemical Formula: C24H28NNaO5 Molecular Weight: 433.4798
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Technical Information	Synonym: AHU377 sodium; LCZ696; AHU 377; LCZ 696; AHU-377; LCZ69 6Chemical Name: sodium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate InChi Key: RRTBVEJIZWGATF-JKSHRDEXSA-M InChi Code: InChI=1S/C24H29NO5.Na/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;+1/p-1/t17-,21+;/m1./s1 SMILES Code: O=C([O-])CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.[Na+]