LAS-31180是一种phosphodiesterase3的抑制剂，能够增强肌肉收缩和血管舒张。
CAS：137338-43-3
分子式：C11H12N2O3S
分子量：252.29
纯度：98%
存储：Store at -20°C

Background:

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].

[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.