DibenzoylThiamine(Bentiamine)是硫胺素的衍生物。在体内被快速吸收到并转化成硫胺素。
CAS：299-88-7
分子式：C26H26N4O4S
分子量：490.57
纯度：98%
存储：Store at -20°C

Background:

Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.

Dibenzoyl Thiamine is a thiol-type thiamine composed of thiamine and benzoic acid. It is not decomposed by aneurinase (thiamine-decomposing enzyme), making it more suitable for food processing than thiamine hydrochloride[1].

A chronic toxicity study in male Wistar rats for 6 months at dietary levels of up to 1000 ppm, shows Dibenzoyl Thiamine to be without specific toxic effects. A teratogenicity study in rats show Dibenzoyl Thiamine to be without embryotoxic or teratogenic effects. Tests for mutagenicity in bacterial systems, in the dominant lethal assay and in an in vivo cytogenetics test show Dibenzoyl Thiamine to be without mutagenic. Dibenzoyl Thiamine is metabolised to Vitamin Br and benzoic acid, and the benzoic acid moiety is almost quantitatively excreted in the urine, as hippuric acid[1].

[1]. Heywood R, et al. Tumorigenic and toxic effect of O,S-dibenzoyl thiamine hydrochloride in prolonged dietaryadministration to rats. Toxicol Lett. 1985 Jul;26(1):53-8.