Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells.
CAS：848035-21-2
分子式：C32H45N3O3.3HCl
分子量：629.1
纯度：98%
存储：Store at -20°C

Background:

Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells.[1] Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively).[2],[3]

Reference:
[1]. Rothschild, A.M. Mechanisms of histamine release by compound 48/80. Br. J. Pharmac. 38(1), 253-262 (1970).
[2]. Adamczyk-Engelmann, P., and Gietzen, K. Induction of histamine release and calmodulin antagonism are two distinct properties of compound 48/80. Cell Calcium 10(2), 93-99 (1989).
[3]. Bronner, C., Charles, W., Didier, M., et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys. Acta. 920(3), 301-305 (1987).