M-89 强效的、特异性的menin 的抑制剂，结合到menin 的Kd 值为1.4 nM。M-89 可抑制Menin-MLL 蛋白之间的相互作用，有治疗混合谱系白血病的潜力。
CAS：2363165-42-6
分子式：C37H47N5O4S
分子量：657.87
纯度：98%
存储：Store at -20°C

Background:

M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1]. Kd: 1.4 nM (menin)[1].

[1]. Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.