Mavoglurantracemate是mavoglurant的外消旋体。Mavoglurant是一种新颖的，非竞争性的mGlu5受体拮抗剂。
CAS：1636881-61-2
分子式：C19H23NO3
分子量：313.39
纯度：98%
存储：Store at -20°C

Background:

Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist.

For antagonistic activity, (-)-mavoglurant, the (-)-enantiomer shows IC50 of 0.11 μM and 0.03 μM (Ca2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1].

[1]. Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803