TP0463518是一种有效的缺氧诱导因子脯氨酰羟化酶(PHDs)抑制剂，作用于人PHD2的Ki值为5.3nM。TP0463518还抑制人PHD1/PHD3，IC50分别为18和63nM，以及猴PHD2，IC50值为22nM。
CAS：1558021-37-6
分子式：C20H18ClN3O6
分子量：431.83
纯度：98%
存储：Store at -20°C

Background:

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

Reference:
[1]. Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144.