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(±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide图片
CAS NO:166100-39-6
规格:98%
分子量:363.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
(±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom.
CAS:166100-39-6
分子式:C23H38FNO
分子量:363.6
纯度:98%
存储:Store at -20°C

Background:

(±)-2-Methyl arachidonoyl-2’-fluoroethylamide (2-Methyl-2’-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor (Ki = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB2 is decreased relative to AEA. However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2’-fluoro AEA is further modified by the addition of an α-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2’-fluoro AEA can fully substitute for δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.