QStatin 是一种有效的选择性弧菌群体感应 (QS) 抑制剂，在不同的弧菌物种中显示出不同的 QS 抑制剂活性。QStatin 减弱了各种弧菌物种中代表性的 QS 调节表型，与 SmcR 中的假定配体结合口袋紧密结合，并改变蛋白质的灵活性，从而改变其转录调节活性。QStatin 可能是一种可用于水产养殖的可持续抗病毒剂。
CAS：902688-24-8
分子式：C7H5BrN2O2S2
分子量：293.16
纯度：98%
存储：Store at -20°C

Background:

QStatin is a novel, potent, and selective Vibrio quorum sensing (QS) inhibitor, shows pan-QS inhibitor activity in diverse Vibrio species. QStatin attenuates representative QS-regulated phenotypes in various Vibrio speciesbinds tightly to a putative ligand-binding pocket in SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity. QStatin may be a sustainable antivibriosis agent useful in aquacultures[1].

[1]. Kim BS, et al. QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species. MBio. 2018 Jan 30;9(1). pii: e02262-17.