MMSET-IN-1 是一种有效的多发性骨髓瘤 SET 域 (MMSET, 又名 NSD2/WHSC1) 抑制剂，抑制 SETD2、MMSET 的 IC50 分别为 0.49、3.3 μM，Kd 值为 1.6 μM。
CAS：1998139-29-9
分子式：C18H29N7O5
分子量：423.47
纯度：98%
存储：Store at -20°C

Background:

MMSET-IN-1 is a multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) inhibitor against SETD2 and MMSET with IC50s of 0.49 and 3.3 μM, respectively. MMSET-IN-1 has a Kd of 1.6 μM for MMSET[1]. IC50: 0.49 μM (SETD2), 3.3 μM (MMSET)[1]Kd: 1.6 μM[1]

[1]. Tisi D, et al. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. ACS Chem Biol. 2016 Nov 18;11(11):3093-3105.