Background:

FH1 is a small molecule that can enhance the functions of cultured hepatocytes [1].

FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].

参考文献:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.