3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage.
CAS：104582-29-8
分子式：C15H25N3O4S3
分子量：407.6
纯度：98%
存储：Store at -20°C

Background:

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage. The carboxyl group of propanoic acid allows biotinylation of targets through either a chemical or enzymatic acylation reaction. The disulfide bond permits removal of the biotin group with reducing agents.

参考文献：

[1]Li, H., Frankenfield, A.M., Housten, R., et al. Thiol-cleavable biotin for chemical and enzymatic biotinylation and its application to mitochondrial TurboID proteomics. J. Am. Soc. Mass Spectrom. (2021). 

[2]Kremer , D.M., Nelson , B.S., Lin, L., et al. GOT1 inhibition primes pancreatic  cancer for ferroptosis  through the autophagic release of labile iron. bioRxiv (2020).