PF-04937319 是一种葡萄糖激酶活化剂 (GKA)，EC50 值为 154.4 μM，有望用来治疗 2 型糖尿病。PF-04937319 旨在维持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。
CAS：1245603-92-2
分子式：C22H20N6O4
分子量：432.43
纯度：98%
存储：Store at -20°C

Background:

PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1].PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2]. EC50: 154.4 μM (GSA) (PF-04937319)[1]

[1]. Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072. [2]. Amin NB, et al. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.