Isosilybin B，一种从 silymarin 中分离的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，抑制癌细胞增殖，诱导 G1 期阻滞和凋亡。Isosilybin B 引起雄激素受体降解。
CAS：142796-22-3
分子式：C25H22O10
分子量：482.44
纯度：98%
存储：Store at -20°C

Background:

Isosilybin B, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation[1][2].

[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.