L-Glutamicacidmonosodiumsalt（Monosodiumglutamate）是mGlu1受体活化剂。
CAS：142-47-2
分子式：C5H8NNaO4
分子量：169.11
纯度：98%
存储：Store at -20°C

Background:

L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.

A single systemic injection of L-Glutamic acid monosodium salt (MSG) (3 g/kg) to PND9 mice causes extensive retinal degeneration and reduces the number of Brn-3a+RGCs by >70% with respect to control mice treated with saline; In mice treated with L-Glutamic acid monosodium salt and JNJ16259685, the number of RGC is reduced by only<20%, and the resulting value is not significantly different from values obtained in all other groups of mice, including control mice. L-Glutamic acid monosodium salt administration to wild-type BALB/c littermates reduces RGC number to a lower extent than in C57BL/6J mice, but the reduction is still highly significant[1].

[1]. Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1.