inactive control of GSK J1, JMJD3 (KDM6B) and UTX (KDM6A) inhibitor
CAS：1394854-52-4
分子式：C22H23N5O2
分子量：389.45
纯度：98%
存储：Store at -20°C

Background:

GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC50 of >100 μM and 49 μM, respectively[1].

参考文献:
[1]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2.