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Itanapraced(CHF5074)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Itanapraced(CHF5074)图片
CAS NO:749269-83-8
规格:98%
分子量:325.16
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Itanapraced(CHF5074)是一种新型γ-secretase调节剂,降低Aβ42和Aβ40分泌,IC50分别为3.6和18.4μM。
CAS:749269-83-8
分子式:C16H11Cl2FO2
分子量:325.16
纯度:98%
存储:Store at -20°C

Background:

Itanapraced (CHF5074) is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.




[1]. Imbimbo BP, et al. 1-(3’,4’-Dichloro-2-fluoro[1,1’-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer’s disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830. [2]. Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.