Handleregionpeptide,rat是肾素原(prorenin)受体拮抗剂，能够抑制糖尿病性肾病的进程，同时对眼部炎症有抵抗作用。
CAS：749227-53-0
分子式：C54H101N15O12 S
分子量：1184.54
纯度：98%
存储：Store at -20°C

Background:

Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.

Handle region peptide, rat is a (pro)renin receptor antagonist. Handle region peptide, rat (1 μM) reduces the ratio of active to total ERK1/2. Handle region peptide, rat (0.1-1 μM) reduces TGF-β1 mRNA level, and inhibits the mesangial cells proliferation in a dose-dependent manner. Handle region peptide, rat (0.01-1 μM) increases the MMP-2 activity[1].

Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2].

[1]. He M, et al. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 Mar 15;606(1-3):155-61. [2]. Satofuka S, et al. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2686-92.