Background:

Sulfadimethoxine is a long acting antibiotic [1].

Sulfadimethoxine is developed as a safe and effective antimicrobial agent for a wide range of infections including acute rhinitis, frontal abscess, pelvic inflammatory disease and upper respiratory infection et al. In the clinical study, sulfadimethoxine is reported to have no side reaction. Besides that, a single dose of 25 mg/kg of sulfadimethoxine is enough for treatment of moderate to severe infection. Most of the patients treated with sulfadimethoxine appear to respond rapidly to the therapy. Sulfadimethoxine is now most frequently used as veterinary medicine. For instance, sulfadimethoxine is found to have anticryptosporidial activity. It is highly effective in reducing the severity of cryptosporidial infection in immunosuppressed-rat model [1, 2].

参考文献:
[1] MOSELY MJ Jr. Clinical results with sulfadimethoxine (madribon); a new long action antibacterial. J Natl Med Assoc. 1959 Jul;51(4):258-62.
[2] Rekg JE, Hancock ML, Woodmansee DB. Anticryptosporidial activity of sulfadimethoxine. Antimicrob Agents Chemother. 1988 Dec;32(12):1907-8.