Menaquinone-7(VitaminK2-7)是维生素K2家族的成员，最早作为抗出血因子被发现。Menaquinone-7(VitaminK2-7)是Gla-蛋白羧化反应中最具生物活性的辅因子。补充Menaquinone-7(VitaminK2-7)也是激活Gla基质蛋白并干预钙化性主动脉瓣狭窄(CAVS)进展的一种药理选择。
CAS：2124-57-4
分子式：C46H64O2
分子量：649
纯度：98%
存储：Store at -20°C

Background:

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

[1]. Thijssen, H H., et al., 1994. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. The British journal of nutrition. 72(3): 415-25. [2]. Conly, J M., et al., 1994. The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. The American journal of gastroenterology. 89(6): 915-23. [3]. Peeters FECM, et al. Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients. 2018 Mar 21;10(4). pii: E386.