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NKH 477
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NKH 477图片
CAS NO:138605-00-2
规格:98%
分子量:546.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
adenylyl cyclase activator
CAS:138605-00-2
分子式:C27H43NO8.HCl
分子量:546.1
纯度:98%
存储:Store at -20°C

Background:

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].


NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1].


参考文献:
[1]. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9.