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MK 886
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK 886图片
CAS NO:118414-82-7
规格:98%
分子量:472.08
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
FLAP and PPARα inhibitor, inhibits leukotriene biosynthesis
CAS:118414-82-7
分子式:C27H34ClNO2S
分子量:472.08
纯度:98%
存储:Store at -20°C

Background:

MK-886 (L 663536) is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).


参考文献:
[1]. [1] Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15.
[2]. [2] Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64.
[3]. [3] Dixon RA et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 1990 Jan 18, 343(6255):282-4.http://www.ncbi.nlm.nih.gov/pubmed/2300173