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Trimidox
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trimidox图片
CAS NO:95933-74-7
规格:98%
分子量:184.2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
specific ribonucleotide reductase inhibitor
CAS:95933-74-7
分子式:C7H8N2O4
分子量:184.2
纯度:98%
存储:Store at -20°C

Background:

Trimidox (3.4.5-tri-hydroxybenzohydroxamidoxime) is a specific and patented ribonucleotide reductase (RNR) inhibitor [1].


Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase, is an enzyme involved in catalyzing the formation of deoxyribonucleotides from ribonucleotides. RNR plays a vital role in regulating the total rate of DNA synthesis to DNA to maintain DNA cell mass a constant ratio during cell division and DNA repair. The substrates for RNR are ADP, GDP, CDP and UDP [2]. Increased ribonucleotide reductase (RNR) activity has been associated with malignant transformation and tumor cell growth [1].


In human promyelocytic leukemia HL-60 cells, trimidox inhibited the growth of with an IC50 of 35 pmol/L. Treatment with trimidox (50 pmol/L) for 24 hours decreased deoxyguanosine triphosphate (dGTP) and deoxycytidine triphosphate (dCTP) pools to 24% and 3946 of control values, respectively. Incubation of HL-60 cells with 20 to 80 pmol/L trimidox to 4 days showed no effects in the distribution of cells indifferent phases of cell cycle [1]. Trimidox in combination with tiazofurin was useful in the treatment of leukemia [1].


参考文献:
[1] Szekeres T, Fritzer M, Strobl H, et al.  Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells[J]. Blood, 1994, 84(12): 4316-4321.
[2] Elledge S J, Zhou Z, Allen J B.  Ribonucleotide reductase: regulation, regulation, regulation[J]. Trends in biochemical sciences, 1992, 17(3): 119-123.