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TAS4464
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAS4464图片
CAS NO:1848959-10-3
规格:98%
分子量:506.51
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
TAS4464 是一种高效选择性的 NEDD8 活化酶 (NAE) 抑制剂,IC50 值为 0.955 nM。
CAS:1848959-10-3
分子式:C21H23FN6O6S
分子量:506.51
纯度:98%
存储:Store at -20°C

Background:

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1]. IC50:0.955 nM (NAE)[1]


TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.



[1]. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.