Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomer.

CAS：1472611-44-1
分子式：C31H32N8O5.C2HF3O2
分子量：710.7
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.1

参考文献：

1.Rodriguez, R., Miller, K.M., Forment, J.V., et al.Small-molecule-induced DNA damage identifies alternative DNA structures in human genesNat. Chem. Biol.8(3)301-310(2012)