六亚甲基双乙酰胺是一种肿瘤细胞分化剂。
货号:ajcx25034
CAS:3073-59-4
分子式:C10H20N2O2
分子量：200.3
溶解度:DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hexamethylene bisacetamide is a tumor cell-differentiating agent.¹It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner.²Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven, but not 28, days reduces tumorigenesis of those cells in mice.³

1.Reuben, R.C., Wife, R.L., Breslow, R., et al.A new group of potent inducers of differentiation in murine erythroleukemia cellsProc. Natl. Acad. Sci. USA73(3)862-866(1976) 2.Contreras, X., Barboric, M., Lenasi, T., et al.HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcriptionPLoS Pathog.3(10)1459-1469(2007) 3.Schroy, P., Winawer, S., and Friedman, E.Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamideCancer Lett.48(1)53-58(1989)