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Acetyl-L-carnitine-d3(chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acetyl-L-carnitine-d3(chloride)图片
规格:98%
分子量:242.7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An internal standard for the quantification of L-acetylcarnitine
货号:ajcx21600
CAS:362049-62-5
分子式:C9H15D3NO4.Cl
分子量:242.7
溶解度:Methanol: slightly soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Acetyl-L-carnitine-d3is intended for use as an internal standard for the quantification of L-acetylcarnitine by GC- or LC-MS. Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine that is catabolized by plasma esterases into carnitine.1,2,3Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis.In vivo, acetyl-L-carnitine (100 mg/kg) increases mGlu2/3 receptor protein levels and mechanical pain thresholds in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant.4


1.Vaz, F.M., and Wanders, R.J.A.Carnitine biosynthesis in mammalsBiochem. J.361(Pt 3)417-429(2002) 2.Fu, L., Huang, M., and Chen, S.Primary carnitine deficiency and cardiomyopathyKorean. Circ. J.43(12)785-792(2013) 3.Stieger, B., O'Neill, B., and KrÄhenbÜhl, S.Characterization of L-carnitine transport by rat kidney brush-border-membrane vesiclesBiochemistry Journal309(Pt 2)643-647(1995) 4.Notartomaso, S., Mascio, G., Bernabucci, M., et al.Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic painMol. Pain13:1744806917697009(2017)