1-HydroxyIbuprofen是Ibuprofen的活性代谢物。Ibuprofen是 COX-1 和COX-2 的抑制剂，IC50 值分别为13μM和370μM，具有抗炎活性。
货号:ajcx29894
CAS:53949-53-4
分子式:C13H18O3
分子量：222.28
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1].

[1]. Yujie He, et al. Metabolism of Ibuprofen by Phragmites australis: Uptake and Phytodegradation. Environ Sci Technol. 2017 Apr 18;51(8):4576-4584. [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.