β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
货号:ajcx19102
CAS:N/A
分子式:C167H256N48O50S6
分子量：3928.5
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of B. adolescentis, L. acidophilus, B. breve, B. vulgatus, L. fermentum, B. longum, and S. thermophilus in an antimicrobial radial diffusion assay. β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius, and of susceptible M. tuberculosis H37Rv but not of resistant M. tuberculosis RM22 when used at a concentration of 128 µg/ml. It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively). Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.