Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and a potent agonist for the FP receptor.
货号:ajcx17640
CAS:N/A
分子式:C23H32O5
分子量：388.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM. The isopropyl ester of bimatoprost is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation. 8-iso-17-phenyl PGF2β is an isomer of bimatoprost that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.