p-Ethynylphenylalanine(4-Ethynyl-L-phenylalanine)是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶(TPH)抑制剂，其Ki值为32.6μM。
货号:ajcx31824
CAS:278605-15-5
分子式:C11H11NO2
分子量：189.21
溶解度:DMSO: 2.22 mg/mL (11.73 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1].

p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1].

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1]

[1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.