Gutrestricted-7(GR-7)是一种有效的，共价和口服活性的泛胆盐水解酶(BSH)抑制剂。Gutrestricted-7可减少小鼠粪便中肠道细菌的BSH活性并降低去结合型胆汁酸水平。
货号:ajcx30746
CAS:2553218-46-3
分子式:C25H40FNaO6S
分子量：510.63
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1].

BSH Inhibitor Gut restricted-7 (GR-7) (60 μM) does not affect epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass[1].

The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (GR-7) (w/w) for 1 d day or powdered chow alone. Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitortreated mice 8 h postdiet change. 20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected[1].

[1]. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326.