QAQ dichloride 是一种可光开关的电压门控 Nav 和 Kv 通道阻断剂，可阻断其反式（偶氮苯光电开关）的通道，但不阻断其顺式形式。
货号:ajcx27066
CAS:N/A
分子式:C28H44Cl2N6O2
分子量：567.59
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID:22343342 |Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID:19882609