A prostaglandin F derivative similar to latanoprost free acid
货号:ajcx21160
CAS:294856-01-2
分子式:C24H33O5F3
分子量：458.5
溶解度:DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

A number of 17-phenyl trinor prostaglandin F_2α(17-phenyl trinor PGF_2α) derivatives have been approved for the treatment of glaucoma.^1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.⁴17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2αwould act very much like the free acid of latanoprost.

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