C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.
货号:ajcx18294
CAS:N/A
分子式:C93H157N27O28S3•XCF3COOH
分子量：2197.6
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities. Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53. CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively). It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM). In vivo, CNP-22 (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.