An active metabolite of bosentan
货号:ajcx25324
CAS:253688-61-8
分子式:C26H27N5O6S
分子量：537.6
溶解度:Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .¹Desmethyl bosentan (25 µM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in a reporter assay.

1.van Giersbergen, P.L.M., Gnerre, C., Treiber, A., et al.Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptorBr. J. Clin. Pharmacol.54(5)561-562(2002)