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Photo-lysine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Photo-lysine hydrochloride图片
规格:98%
分子量:245.11
包装与价格:
包装价格(元)
5mg电议
10mg电议
20mg电议

产品介绍
Photo-lysinehydrochloride,一种新的基于赖氨酸光反应性的氨基酸,它捕获结合赖氨酸翻译后修饰的蛋白质。
货号:ajcx13326
CAS:N/A
分子式:C6H14Cl2N4O2
分子量:245.11
溶解度:H2O : ≥ 40 mg/mL (163.19 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Photo-lysine hydrochloride, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including 'readers' and 'erasers' of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1].


[1]. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2.