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Transdermal Peptide Disulfide TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Transdermal Peptide Disulfide TFA图片
规格:98%
分子量:1175.17
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
TransdermalPeptideDisulfideTFA(TD1Disulfide(peptide)TFA)是由11个氨基酸组成的多肽,可以与Na+/K+-ATPasebeta-subunit(ATP1B1)结合,主要与ATP1B1的C末端相互作用。TransdermalPeptideDisulfideTFA能够增强一些大分子在皮肤中的传递。
货号:ajcx31598
CAS:N/A
分子式:C42H65F3N14O18S2
分子量:1175.17
溶解度:H2O: 100 mg/mL (85.09 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules[1].

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin[1].


[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.