Mc-VC-PAB-SN38由可降解(cleavable)的ADClinker(Mc-VC-PAB)和SN38组成，SN38是一种DNA拓扑异构酶I抑制剂。Mc-VC-PAB-SN38可用于合成抗体偶联药物(ADC)。
货号:ajcx31010
CAS:1801838-28-7
分子式:C51H58N8O13
分子量：991.05
溶解度:DMSO: 28.57 mg/mL (28.83 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.