An internal standard for the quantification of N-desmethylclozapine
货号:ajcx23078
CAS:1189888-77-4
分子式:C17H9ClD8N4
分子量：320.9
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-Desmethylclozapine-d₈is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine .¹It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT_2C(IC₅₀= 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.^2,3N-Desmethylclozapine is an antagonist at dopamine D₄receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D₂and D₃, M₁muscarinic acetylcholine, and 5-HT_1Areceptors.^3,1,4N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.⁵

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