SPI 112 是一种有效、选择性和竞争性的 SHP2 (PTPN11) 抑制剂，对 SHP2、蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的 IC50 分别为 1 μM、18.3 μM 和 14.5 μM。
货号:ajcx20384
CAS:1051387-90-6
分子式:C22H17FN4O5S
分子量：468.5
溶解度:DMF: 1 mg/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 μM).1 It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 μM, respectively).

|1. Lawrence, H.R., Pireddu, R., Chen, L., et al. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J. Med. Chem. 51(16), 4548-4956 (2008).