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WJ460
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WJ460图片
规格:98%
分子量:460.59
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
WJ460 是一种有效的肌成纤维蛋白 (MYOF) 抑制剂,可与 MYOF 直接相互作用,并在乳腺癌细胞的纳摩尔范围内发挥抗转移活性。
货号:ajcx14454
CAS:1415251-36-3
分子式:C27H28N2O3S
分子量:460.59
溶解度:DMSO: 250 mg/mL (542.78 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

WJ460 is a potent myoferlin (MYOF) inhibitor, which interacts directly with MYOF and exerts anti-metastatic activity in the nanomolar range in breast cancer cells[1].

WJ460 blocks breast cancer cell invasion with IC50 values of 43.37 ± 3.42 nM in MDA-MB-231 and 36.40 ± 4.51 nM in BT549 cells. WJ460 treatment remarkably inhibits MDA-MB-231 and BT549 cell invasion through Collagen I in a dose-dependent manner[1].

WJ460 inhibits breast tumor growth, angiogenesis, and spontaneous metastasis in a spontaneous metastasis model[1].

[1]. Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726.