DesmorpholinylNavitoclax-NH-Me是一种Bcl-xL抑制剂。DesmorpholinylNavitoclax-NH-Me和E3泛素连接酶的CRBN配体可用来合成PROTACBCL-XL降解剂XZ739。
货号:ajcx30496
CAS:2365172-82-1
分子式:C44H51ClF3N5O5S3
分子量：918.55
溶解度:DMSO: 100 mg/mL (108.87 mM); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 [1][2].

[1]. Guangrong Zheng, et al. Agents de dÉgradation de protÉines bcl-2 pour le traitement du cancer. WO2019144117A1.