Tesofensine (NS-2330) 是一种三元单胺再摄取抑制剂，可有效抑制神经递质多巴胺 (DA; IC50=6.5 nM)、去甲肾上腺素 (NE;IC50=1.7 nM) 和5-羟色胺 (5-HT;IC50=11 nM)，具有作为抗肥胖剂的潜力。
货号:ajcx28448
CAS:195875-84-4
分子式:C17H23Cl2NO
分子量：328.3
溶解度:DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tesofensine is a triple monoamine reuptake inhibitor that inhibits norepinephrine, serotonin (5-HT), and dopamine reuptake function.¹,²In vivo, tesofensine (2 mg/kg, s.c.) reduces body weight and food intake in a rat model of high-fat diet-induced obesity.¹

1.Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H.Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese ratNeuropsychopharmacology35(7)1464-1476(2010) 2.van de Giessen, E., de Bruin, K., la Fleur, S.E., et al.Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese ratsEur. Neuropsychopharmacol.22(4)290-299(2012)