GX 201 是一种选择性 NaV1.7 抑制剂，对 hNaV1.7 的 IC50 \u003c3.2 nM。
货号:ajcx28088
CAS:1788071-27-1
分子式:C25H27ClF4N2O4S
分子量：563
溶解度:DMSO|56.3|100|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective Nav1.7 blocker (IC50 = 3.2 nM). Exhibits 10x selectivity for Nav1.7 over Nav1.1, Nav1.2, and Nav1.6 channels. Displays prolonged residency time on the Nav1.7 channel. Chronic dosing increases compound potency ~10-fold and provides efficacy that persists after the compound has cleared from plasma. Suppresses neuropathic pain in a mouse diabetic neuropathy model. Analgesic.